Immunohistochemical Expression of Heparanase-2 in Psoriasis

Background: Psoriasis is a chronic, inflammatory immune mediated skin disease characterized by dense infiltrates of immunocytes especially macrophages. Cross talk between and keratinocytes thought to mediate the disease. Hparanase 2 inhibits activity Heparanase 1 which involved in this cross degradation heparin sulphate chains basement membrane extra cellular matrix (ECM). Objective: To assess Heparanase2 psoriasis through its immunohistochemical expression lesional perilesional patients. Patients Methods: This prospective case control study was carried out on total number 60 subjects, they included 30 patients with chronic plaque age gender matched apparently normal subjects as group. Skin biopsies were taken for evaluation expression. Results: Our results showed significant difference lesional, groups regarding status epidermal (P = 0.038). All negative while 24 (80%) cases positive 6 (20%) cases, 27 (90%) 3 (10%) cases. There no three studied dermal 0.318). Conclusion: Downregulation could be incriminated pathogenesis psoriasis. have protective role skin.